BDBM50522014 CHEMBL4460657

SMILES: CN1CCN(CC1)c1sc(NC(=O)c2cnn(c2C)-c2ccc(F)cc2)nc1C1CCC1

InChI Key: InChIKey=TVIMYRBJYTWVRP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522014   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50522014 (CHEMBL4460657) Show SMILES CN1CCN(CC1)c1sc(NC(=O)c2cnn(c2C)-c2ccc(F)cc2)nc1C1CCC1 Show InChI InChI=1S/C23H27FN6OS/c1-15-19(14-25-30(15)18-8-6-17(24)7-9-18)21(31)27-23-26-20(16-4-3-5-16)22(32-23)29-12-10-28(2)11-13-29/h6-9,14,16H,3-5,10-13H2,1-2H3,(H,26,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye based				Bioorg Med Chem 27: 3775-3787 (2019) Article DOI: 10.1016/j.bmc.2019.05.041
					More data for this Ligand-Target Pair