null
SMILES: COc1cc2c(Nc3ccc(NC(=O)C(N4Cc5ccccc5C4=O)c4cc(F)ccc4F)cc3F)ncnc2cc1OCC1CCN(C)CC1
InChI Key: InChIKey=RNUUQLALKWVVSI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50525411 (CHEMBL4443483) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant expressed in baculov... | ACS Med Chem Lett 10: 869-873 (2019) Article DOI: 10.1021/acsmedchemlett.8b00564 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50525411 (CHEMBL4443483) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 331 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of EGFR 19D/T790M/C797S mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA | ACS Med Chem Lett 10: 869-873 (2019) Article DOI: 10.1021/acsmedchemlett.8b00564 | |||||||||||
More data for this Ligand-Target Pair |