Found 4 hits for monomerid = 50525697 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50525697
(CHEMBL4457318)Show SMILES COc1ncc(cc1C#N)-c1ccc2ncnc(N[C@H]3CCCN(C3)C(=O)c3coc(c3)[N+]([O-])=O)c2c1 |r| Show InChI InChI=1S/C25H21N7O5/c1-36-24-16(10-26)7-17(11-27-24)15-4-5-21-20(8-15)23(29-14-28-21)30-19-3-2-6-31(12-19)25(33)18-9-22(32(34)35)37-13-18/h4-5,7-9,11,13-14,19H,2-3,6,12H2,1H3,(H,28,29,30)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Inhibition of PI3K alpha (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of ATP by Kinase-Glo Plus reage... |
Bioorg Med Chem 27: (2019)
Article DOI: 10.1016/j.bmc.2019.07.051 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50525697
(CHEMBL4457318)Show SMILES COc1ncc(cc1C#N)-c1ccc2ncnc(N[C@H]3CCCN(C3)C(=O)c3coc(c3)[N+]([O-])=O)c2c1 |r| Show InChI InChI=1S/C25H21N7O5/c1-36-24-16(10-26)7-17(11-27-24)15-4-5-21-20(8-15)23(29-14-28-21)30-19-3-2-6-31(12-19)25(33)18-9-22(32(34)35)37-13-18/h4-5,7-9,11,13-14,19H,2-3,6,12H2,1H3,(H,28,29,30)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Inhibition of PI3K beta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of ATP by Kinase-Glo Plus reagen... |
Bioorg Med Chem 27: (2019)
Article DOI: 10.1016/j.bmc.2019.07.051 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50525697
(CHEMBL4457318)Show SMILES COc1ncc(cc1C#N)-c1ccc2ncnc(N[C@H]3CCCN(C3)C(=O)c3coc(c3)[N+]([O-])=O)c2c1 |r| Show InChI InChI=1S/C25H21N7O5/c1-36-24-16(10-26)7-17(11-27-24)15-4-5-21-20(8-15)23(29-14-28-21)30-19-3-2-6-31(12-19)25(33)18-9-22(32(34)35)37-13-18/h4-5,7-9,11,13-14,19H,2-3,6,12H2,1H3,(H,28,29,30)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Inhibition of PI3K delta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of ATP by Kinase-Glo Plus reage... |
Bioorg Med Chem 27: (2019)
Article DOI: 10.1016/j.bmc.2019.07.051 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50525697
(CHEMBL4457318)Show SMILES COc1ncc(cc1C#N)-c1ccc2ncnc(N[C@H]3CCCN(C3)C(=O)c3coc(c3)[N+]([O-])=O)c2c1 |r| Show InChI InChI=1S/C25H21N7O5/c1-36-24-16(10-26)7-17(11-27-24)15-4-5-21-20(8-15)23(29-14-28-21)30-19-3-2-6-31(12-19)25(33)18-9-22(32(34)35)37-13-18/h4-5,7-9,11,13-14,19H,2-3,6,12H2,1H3,(H,28,29,30)/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Xi'an Jiaotong University
Curated by ChEMBL
| Assay Description
Inhibition of PI3K gamma (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of ATP by Kinase-Glo Plus reage... |
Bioorg Med Chem 27: (2019)
Article DOI: 10.1016/j.bmc.2019.07.051 |
More data for this
Ligand-Target Pair | |
Search and Browse
