BindingDB PrimarySearch

null

SMILES: CC(C)(C)c1cc(NC(=O)COC(=O)c2ccc(cc2)-n2cnnn2)n(n1)-c1ccccc1

InChI Key: InChIKey=PRZQRZSCFWKYBL-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50525706
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transcription factor NF-E2 45 kDa subunit (Homo sapiens)	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	113	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of activated recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide...				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of activated recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide...				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of inactive recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide ...				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of inactive recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide ...				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system incubated with enzyme/ATP...				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of recombinant full length human TrkA transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of recombinant full length human TrkB transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assay				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Rattus norvegicus)	BDBM50525706 (CHEMBL4447685) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	429	n/a	n/a	n/a	n/a	n/a	n/a
Zoetis Curated by ChEMBL					Assay Description Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth incubated for 7 days by live cell imaging analysis				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126624
Zoetis Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)