BDBM50526325 CHEMBL4438880::US10752616, Code No. BHBA-021

SMILES: Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O

InChI Key: InChIKey=XFZDQLMCBCSXIC-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50526325   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta (Homo sapiens (Human))	BDBM50526325 (CHEMBL4438880 | US10752616, Code No. BHBA-021) Show SMILES Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O3S/c1-10-3-4-11(2)16-14(10)9-15(25-16)18-20-17(21-24-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
King''s College London US Patent					Assay Description Transcriptional transactivation assays were performed with gal4 fusion receptor constructs, created using each of the RAR ligand binding domains of e...				US Patent US10752616 (2020)
					More data for this Ligand-Target Pair
Retinoic acid receptor alpha/Retinoid X receptor alpha (Homo sapiens (Human))	BDBM50526325 (CHEMBL4438880 | US10752616, Code No. BHBA-021) Show SMILES Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O3S/c1-10-3-4-11(2)16-14(10)9-15(25-16)18-20-17(21-24-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
King''s College London US Patent					Assay Description Transcriptional transactivation assays were performed with gal4 fusion receptor constructs, created using each of the RAR ligand binding domains of e...				US Patent US10752616 (2020)
					More data for this Ligand-Target Pair
Retinoic acid receptor alpha (Mus musculus)	BDBM50526325 (CHEMBL4438880 | US10752616, Code No. BHBA-021) Show SMILES Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O3S/c1-10-3-4-11(2)16-14(10)9-15(25-16)18-20-17(21-24-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
King's College Curated by ChEMBL					Assay Description Transactivation of GAL4-fused mouse RARalpha-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay				Bioorg Med Chem Lett 29: 995-1000 (2019) Article DOI: 10.1016/j.bmcl.2019.02.011
					More data for this Ligand-Target Pair
Retinoic acid receptor gamma (Mus musculus)	BDBM50526325 (CHEMBL4438880 | US10752616, Code No. BHBA-021) Show SMILES Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O3S/c1-10-3-4-11(2)16-14(10)9-15(25-16)18-20-17(21-24-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
King's College Curated by ChEMBL					Assay Description Transactivation of GAL4-fused mouse RARgamma-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay				Bioorg Med Chem Lett 29: 995-1000 (2019) Article DOI: 10.1016/j.bmcl.2019.02.011
					More data for this Ligand-Target Pair
Retinoic acid receptor beta (Mus musculus)	BDBM50526325 (CHEMBL4438880 | US10752616, Code No. BHBA-021) Show SMILES Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O3S/c1-10-3-4-11(2)16-14(10)9-15(25-16)18-20-17(21-24-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
King's College Curated by ChEMBL					Assay Description Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay				Bioorg Med Chem Lett 29: 995-1000 (2019) Article DOI: 10.1016/j.bmcl.2019.02.011
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha/gamma (Homo sapiens (Human))	BDBM50526325 (CHEMBL4438880 | US10752616, Code No. BHBA-021) Show SMILES Cc1ccc(C)c2sc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C19H14N2O3S/c1-10-3-4-11(2)16-14(10)9-15(25-16)18-20-17(21-24-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a
King''s College London US Patent					Assay Description Transcriptional transactivation assays were performed with gal4 fusion receptor constructs, created using each of the RAR ligand binding domains of e...				US Patent US10752616 (2020)
					More data for this Ligand-Target Pair