BDBM50526963 CHEMBL4456922

SMILES: Cc1cc(cn(C)c1=O)-c1nc2ccccc2n1CC1CCOCC1

InChI Key: InChIKey=IWELMDBRVJWCNU-UHFFFAOYSA-N

Data: 2 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50526963   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50526963 (CHEMBL4456922) Show SMILES Cc1cc(cn(C)c1=O)-c1nc2ccccc2n1CC1CCOCC1 Show InChI InChI=1S/C20H23N3O2/c1-14-11-16(13-22(2)20(14)24)19-21-17-5-3-4-6-18(17)23(19)12-15-7-9-25-10-8-15/h3-6,11,13,15H,7-10,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
GSK Curated by ChEMBL					Assay Description Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...				J Med Chem 63: 714-746 (2020) Article DOI: 10.1021/acs.jmedchem.9b01670
					More data for this Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A (Homo sapiens (Human))	BDBM50526963 (CHEMBL4456922) Show SMILES Cc1cc(cn(C)c1=O)-c1nc2ccccc2n1CC1CCOCC1 Show InChI InChI=1S/C20H23N3O2/c1-14-11-16(13-22(2)20(14)24)19-21-17-5-3-4-6-18(17)23(19)12-15-7-9-25-10-8-15/h3-6,11,13,15H,7-10,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
GSK Curated by ChEMBL					Assay Description Inhibition of BAZ2A (unknown origin) by TR-FRET assay				J Med Chem 63: 714-746 (2020) Article DOI: 10.1021/acs.jmedchem.9b01670
					More data for this Ligand-Target Pair