BDBM50527360 CHEMBL4456874::US10829446, Compound 71

SMILES: Cc1ccn(n1)-c1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F

InChI Key: InChIKey=LHSITODGOANROC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50527360   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone acetyltransferase KAT6A (Homo sapiens)	BDBM50527360 (CHEMBL4456874 | US10829446, Compound 71) Show SMILES Cc1ccn(n1)-c1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F Show InChI InChI=1S/C17H14F2N4O3S/c1-11-6-7-23(21-11)14-9-12(8-13(18)10-14)17(24)20-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,20,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
MONASH UNIVERSITY; The Walter and Eliza Hall Institute of Medical Research US Patent					Assay Description Active Moz protein was expressed as N-terminal fusion protein with a His6 tag in BL21 E. coli cells. Protein purification was performed via nickel-im...				US Patent US10829446 (2020)
					More data for this Ligand-Target Pair
Histone acetyltransferase KAT6A (Homo sapiens)	BDBM50527360 (CHEMBL4456874 | US10829446, Compound 71) Show SMILES Cc1ccn(n1)-c1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F Show InChI InChI=1S/C17H14F2N4O3S/c1-11-6-7-23(21-11)14-9-12(8-13(18)10-14)17(24)20-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,20,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...				J Med Chem 63: 4655-4684 (2020) Article DOI: 10.1021/acs.jmedchem.9b02071
					More data for this Ligand-Target Pair