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BDBM50527400 CHEMBL4474925

SMILES: Oc1ccc(-c2n[nH]c(c2-c2ccccc2)C(F)(F)F)c(O)c1O

InChI Key: InChIKey=UPXHGXCRVGIYHF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50527400   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen synthase (GYS1)


(Homo sapiens (Human))		BDBM50527400
PNG
(CHEMBL4474925)
Show SMILES Oc1ccc(-c2n[nH]c(c2-c2ccccc2)C(F)(F)F)c(O)c1O
Show InChI InChI=1S/C16H11F3N2O3/c17-16(18,19)15-11(8-4-2-1-3-5-8)12(20-21-15)9-6-7-10(22)14(24)13(9)23/h1-7,22-24H,(H,20,21)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.64E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of C-terminal 6His-tagged wild type human GYS1 using UDPG as substrate in presence of 1 mM G-6-P by 14C-glucose incorporation assay

J Med Chem 63: 3538-3551 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01851
More data for this
Ligand-Target Pair