BDBM50529449 CHEMBL4449727

SMILES: Fc1ccc(CN2CCN(CC2=O)c2cn[nH]c(=O)c2Cl)c(c1)C(F)(F)F

InChI Key: InChIKey=PPGTXNCAMZXQKT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50529449   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor protein 5 (TRPC5) (Homo sapiens (Human))	BDBM50529449 (CHEMBL4449727) Show SMILES Fc1ccc(CN2CCN(CC2=O)c2cn[nH]c(=O)c2Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C16H13ClF4N4O2/c17-14-12(6-22-23-15(14)27)24-3-4-25(13(26)8-24)7-9-1-2-10(18)5-11(9)16(19,20)21/h1-2,5-6H,3-4,7-8H2,(H,23,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Goldfinch Bio Inc. Curated by ChEMBL					Assay Description Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with hol...				ACS Med Chem Lett 10: 1579-1585 (2019) Article DOI: 10.1021/acsmedchemlett.9b00430
					More data for this Ligand-Target Pair