null

SMILES: C[C@](O)(CN1CCc2cc(F)c(F)cc12)C(=O)Nc1ccc(C#N)c(Cl)c1

InChI Key: InChIKey=UPTPZDHQUUSVAL-IBGZPJMESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50529669   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Androgen receptor (Homo sapiens (Human))	BDBM50529669 (CHEMBL4521365) Show SMILES C[C@](O)(CN1CCc2cc(F)c(F)cc12)C(=O)Nc1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C19H16ClF2N3O2/c1-19(27,18(26)24-13-3-2-12(9-23)14(20)7-13)10-25-5-4-11-6-15(21)16(22)8-17(11)25/h2-3,6-8,27H,4-5,10H2,1H3,(H,24,26)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	252	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50529669 (CHEMBL4521365) Show SMILES C[C@](O)(CN1CCc2cc(F)c(F)cc12)C(=O)Nc1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C19H16ClF2N3O2/c1-19(27,18(26)24-13-3-2-12(9-23)14(20)7-13)10-25-5-4-11-6-15(21)16(22)8-17(11)25/h2-3,6-8,27H,4-5,10H2,1H3,(H,24,26)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	252	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50529669 (CHEMBL4521365) Show SMILES C[C@](O)(CN1CCc2cc(F)c(F)cc12)C(=O)Nc1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C19H16ClF2N3O2/c1-19(27,18(26)24-13-3-2-12(9-23)14(20)7-13)10-25-5-4-11-6-15(21)16(22)8-17(11)25/h2-3,6-8,27H,4-5,10H2,1H3,(H,24,26)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50529669 (CHEMBL4521365) Show SMILES C[C@](O)(CN1CCc2cc(F)c(F)cc12)C(=O)Nc1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C19H16ClF2N3O2/c1-19(27,18(26)24-13-3-2-12(9-23)14(20)7-13)10-25-5-4-11-6-15(21)16(22)8-17(11)25/h2-3,6-8,27H,4-5,10H2,1H3,(H,24,26)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Science Center Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...				J Med Chem 62: 491-511 (2019) Article DOI: 10.1021/acs.jmedchem.8b00973
					More data for this Ligand-Target Pair