BindingDB PrimarySearch

BDBM50529754 CHEMBL579353::GNF-Pf-2789

SMILES: CCN(CC)CCCC(C)Nc1nc(\C=C\c2cc(OC)c(OC)cc2Cl)nc2cc(Cl)ccc12

InChI Key: InChIKey=ZEHGJPVTWNYYHP-JLHYYAGUSA-N

Data: 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50529754
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Receptor protein-tyrosine kinase erbB-4 (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human ERBB4 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human LYN-B using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
CaM kinase I gamma (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human CAMK1G using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human CSK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human CSK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human LYN-B using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
CaM kinase I gamma (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human CAMK1G using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-4 (Homo sapiens (Human))	BDBM50529754 (CHEMBL579353 \| GNF-Pf-2789) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia in Katowice Curated by ChEMBL					Assay Description Inhibition of human ERBB4 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 163: 610-625 (2019) Article DOI: 10.1016/j.ejmech.2018.12.012
University of Silesia in Katowice Curated by ChEMBL					More data for this Ligand-Target Pair