Found 8 hits for monomerid = 50530792 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
JAK3/JAK1
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of JAK1/3 in human Ramos cells harboring beta-lactamase reporter gene assessed as reduction in IL4-induced STAT6 phosphorylation incubated... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
JAK3/JAK1
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of JAK1/3 in human Ramos cells harboring beta-lactamase reporter gene assessed as reduction in IL4-induced STAT6 phosphorylation incubated... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50530792
(CHEMBL4526485)Show SMILES Clc1c[nH]c(=O)c(Nc2ncc3[nH]c(=O)n([C@H]4CC[C@H](CC#N)CC4)c3n2)c1 |r,wU:16.15,wD:19.19,(27.52,-36.41,;26.19,-37.18,;24.85,-36.4,;23.52,-37.18,;23.53,-38.72,;22.2,-39.49,;24.85,-39.48,;24.85,-41.02,;26.19,-41.79,;26.18,-43.33,;27.52,-44.1,;28.85,-43.33,;30.32,-43.8,;31.23,-42.55,;32.77,-42.55,;30.32,-41.31,;30.79,-39.84,;29.76,-38.71,;30.24,-37.25,;31.75,-36.93,;32.22,-35.47,;33.72,-35.15,;35.22,-34.83,;32.77,-38.07,;32.3,-39.53,;28.85,-41.78,;27.52,-41.02,;26.19,-38.71,)| Show InChI InChI=1S/C18H18ClN7O2/c19-11-7-13(16(27)21-8-11)23-17-22-9-14-15(25-17)26(18(28)24-14)12-3-1-10(2-4-12)5-6-20/h7-10,12H,1-5H2,(H,21,27)(H,24,28)(H,22,23,25)/t10-,12- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s... |
J Med Chem 62: 9045-9060 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00533 |
More data for this
Ligand-Target Pair | |
Search and Browse
