BDBM50531813 CHEMBL4542373

SMILES: CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nncs1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

InChI Key: InChIKey=PFWAXGUKYRAYAJ-DXCNDIKUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50531813   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
20S proteasome (Homo sapiens (Human))	BDBM50531813 (CHEMBL4542373) Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nncs1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C33H47N7O6S/c1-20(2)15-24(27(41)33(5)18-46-33)35-30(44)26(17-22-9-7-6-8-10-22)36-29(43)25(16-21(3)4)37-32(45)40-13-11-23(12-14-40)28(42)38-31-39-34-19-47-31/h6-10,19-21,23-26H,11-18H2,1-5H3,(H,35,44)(H,36,43)(H,37,45)(H,38,39,42)/t24-,25-,26-,33+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Institute of Innovative Medicine Curated by ChEMBL					Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition				Eur J Med Chem 164: 602-614 (2019) Article DOI: 10.1016/j.ejmech.2018.12.064
					More data for this Ligand-Target Pair