BDBM50531825 CHEMBL4435814

SMILES: CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccon1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

InChI Key: InChIKey=GCAGLVKLOWGBCV-CBUCOWSNSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50531825   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
20S proteasome (Homo sapiens (Human))	BDBM50531825 (CHEMBL4435814) Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccon1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C34H48N6O7/c1-21(2)17-25(29(41)34(5)20-46-34)35-32(44)27(19-23-9-7-6-8-10-23)36-31(43)26(18-22(3)4)37-33(45)40-14-11-24(12-15-40)30(42)38-28-13-16-47-39-28/h6-10,13,16,21-22,24-27H,11-12,14-15,17-20H2,1-5H3,(H,35,44)(H,36,43)(H,37,45)(H,38,39,42)/t25-,26-,27-,34+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Institute of Innovative Medicine Curated by ChEMBL					Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition				Eur J Med Chem 164: 602-614 (2019) Article DOI: 10.1016/j.ejmech.2018.12.064
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