Found 8 hits for monomerid = 50532437 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Carbonic anhydrase 12
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
Carbonic anhydrase 12
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 9 catalytic site preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 9 catalytic site preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM50532437
(CHEMBL4456743)Show SMILES O=C(Nc1cccc2c1C(=O)NS2(=O)=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H14N2O4S/c23-19(15-11-9-14(10-12-15)13-5-2-1-3-6-13)21-16-7-4-8-17-18(16)20(24)22-27(17,25)26/h1-12H,(H,21,23)(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay |
J Med Chem 59: 6547-52 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00616 |
More data for this
Ligand-Target Pair | |
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