BDBM50532615 CHEMBL4549408

SMILES: CCNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F

InChI Key: InChIKey=HGGIFNLRPYEBQB-LBPRGKRZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50532615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50532615 (CHEMBL4549408) Show SMILES CCNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H20ClF3N6O/c1-2-23-16-24-7-5-15(27-16)28-8-6-12(10-28)26-17(29)25-11-3-4-14(19)13(9-11)18(20,21)22/h3-5,7,9,12H,2,6,8,10H2,1H3,(H,23,24,27)(H2,25,26,29)/t12-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50532615 (CHEMBL4549408) Show SMILES CCNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H20ClF3N6O/c1-2-23-16-24-7-5-15(27-16)28-8-6-12(10-28)26-17(29)25-11-3-4-14(19)13(9-11)18(20,21)22/h3-5,7,9,12H,2,6,8,10H2,1H3,(H,23,24,27)(H2,25,26,29)/t12-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysis				ACS Med Chem Lett 7: 595-600 (2016) Article DOI: 10.1021/acsmedchemlett.6b00044
					More data for this Ligand-Target Pair