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BDBM50533488 CHEMBL4580050

SMILES: Cc1cn(cn1)-c1ccc(cc1F)-c1csc(Nc2c3CCCc3nn2CCO)n1

InChI Key: InChIKey=WNJNPYVLMWCMBP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50533488   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50533488
PNG
(CHEMBL4580050)
Show SMILES Cc1cn(cn1)-c1ccc(cc1F)-c1csc(Nc2c3CCCc3nn2CCO)n1
Show InChI InChI=1S/C21H21FN6OS/c1-13-10-27(12-23-13)19-6-5-14(9-16(19)22)18-11-30-21(24-18)25-20-15-3-2-4-17(15)26-28(20)7-8-29/h5-6,9-12,29H,2-4,7-8H2,1H3,(H,24,25)
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...

Bioorg Med Chem Lett 26: 3928-37 (2016)


Article DOI: 10.1016/j.bmcl.2016.07.011
More data for this
Ligand-Target Pair