BDBM50533520 CHEMBL4561383

SMILES: Cc1cn(cn1)-c1ccc(cc1F)-c1csc(Nc2c3CCCCc3nn2C2CCOC2)n1

InChI Key: InChIKey=JBMSMGKOHRDXDB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50533520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50533520 (CHEMBL4561383) Show SMILES Cc1cn(cn1)-c1ccc(cc1F)-c1csc(Nc2c3CCCCc3nn2C2CCOC2)n1 Show InChI InChI=1S/C24H25FN6OS/c1-15-11-30(14-26-15)22-7-6-16(10-19(22)25)21-13-33-24(27-21)28-23-18-4-2-3-5-20(18)29-31(23)17-8-9-32-12-17/h6-7,10-11,13-14,17H,2-5,8-9,12H2,1H3,(H,27,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	289	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by EL...				Bioorg Med Chem Lett 26: 3928-37 (2016) Article DOI: 10.1016/j.bmcl.2016.07.011
					More data for this Ligand-Target Pair