BDBM50535092 CHEMBL4469541

SMILES: CN(C)c1ccc(cn1)-c1cc2nccnc2c(NCCC(N)=O)n1

InChI Key: InChIKey=RQIHWUXZUCCRLQ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50535092   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50535092 (CHEMBL4469541) Show SMILES CN(C)c1ccc(cn1)-c1cc2nccnc2c(NCCC(N)=O)n1 Show InChI InChI=1S/C17H19N7O/c1-24(2)15-4-3-11(10-22-15)12-9-13-16(20-8-7-19-13)17(23-12)21-6-5-14(18)25/h3-4,7-10H,5-6H2,1-2H3,(H2,18,25)(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...				Bioorg Med Chem Lett 26: 4606-4612 (2016) Article DOI: 10.1016/j.bmcl.2016.08.070
					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50535092 (CHEMBL4469541) Show SMILES CN(C)c1ccc(cn1)-c1cc2nccnc2c(NCCC(N)=O)n1 Show InChI InChI=1S/C17H19N7O/c1-24(2)15-4-3-11(10-22-15)12-9-13-16(20-8-7-19-13)17(23-12)21-6-5-14(18)25/h3-4,7-10H,5-6H2,1-2H3,(H2,18,25)(H,21,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<5.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHOK1 cell membranes after 2 hrs by cy3b-dofetilide-based fluorescence polarization assay				Bioorg Med Chem Lett 26: 4606-4612 (2016) Article DOI: 10.1016/j.bmcl.2016.08.070
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50535092 (CHEMBL4469541) Show SMILES CN(C)c1ccc(cn1)-c1cc2nccnc2c(NCCC(N)=O)n1 Show InChI InChI=1S/C17H19N7O/c1-24(2)15-4-3-11(10-22-15)12-9-13-16(20-8-7-19-13)17(23-12)21-6-5-14(18)25/h3-4,7-10H,5-6H2,1-2H3,(H2,18,25)(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of SYK in human B cells assessed as suppression of anti-IgM-induced CD69 surface expression preincubated for 30 mins followed by anti-IgM ...				Bioorg Med Chem Lett 26: 4606-4612 (2016) Article DOI: 10.1016/j.bmcl.2016.08.070
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50535092 (CHEMBL4469541) Show SMILES CN(C)c1ccc(cn1)-c1cc2nccnc2c(NCCC(N)=O)n1 Show InChI InChI=1S/C17H19N7O/c1-24(2)15-4-3-11(10-22-15)12-9-13-16(20-8-7-19-13)17(23-12)21-6-5-14(18)25/h3-4,7-10H,5-6H2,1-2H3,(H2,18,25)(H,21,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of N-terminal-6His-tagged full length human Aurora B expressed in baculovirus using 5FAM-PKA-tide as substrate after 120 mins by fluoresce...				Bioorg Med Chem Lett 26: 4606-4612 (2016) Article DOI: 10.1016/j.bmcl.2016.08.070
					More data for this Ligand-Target Pair