BDBM50536478 CHEMBL4554813

SMILES: COC(=O)c1ccc(cc1F)-c1cnc2ncn(C(C)c3c(F)cc4ncccc4c3F)c2n1

InChI Key: InChIKey=MXEBEIURWAMTGV-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50536478   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50536478 (CHEMBL4554813) Show SMILES COC(=O)c1ccc(cc1F)-c1cnc2ncn(C(C)c3c(F)cc4ncccc4c3F)c2n1 Show InChI InChI=1S/C24H16F3N5O2/c1-12(20-17(26)9-18-15(21(20)27)4-3-7-28-18)32-11-30-22-23(32)31-19(10-29-22)13-5-6-14(16(25)8-13)24(33)34-2/h3-12H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a
Shanghai Pharmaceuticals Holding Co., Ltd Curated by ChEMBL					Assay Description Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...				Bioorg Med Chem 24: 4281-4290 (2016) Article DOI: 10.1016/j.bmc.2016.07.019
					More data for this Ligand-Target Pair