BindingDB logo
myBDB logout

BDBM50536548 CHEMBL4527506

SMILES: CCC(c1cc2cccnc2cc1F)n1cnc2ncc(nc12)-c1ccc(C(N)=O)c(F)c1

InChI Key: InChIKey=KHPDLHZZWSZHGE-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50536548   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50536548
PNG
(CHEMBL4527506)
Show SMILES CCC(c1cc2cccnc2cc1F)n1cnc2ncc(nc12)-c1ccc(C(N)=O)c(F)c1
Show InChI InChI=1S/C24H18F2N6O/c1-2-21(16-8-13-4-3-7-28-19(13)10-18(16)26)32-12-30-23-24(32)31-20(11-29-23)14-5-6-15(22(27)33)17(25)9-14/h3-12,21H,2H2,1H3,(H2,27,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.5n/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...

Bioorg Med Chem 24: 4281-4290 (2016)


Article DOI: 10.1016/j.bmc.2016.07.019
More data for this
Ligand-Target Pair