null

SMILES: O=C1N[C@@H]([C@H](O1)c1ccccc1)c1cccc(c1)C#Cc1ccccc1

InChI Key: InChIKey=WNOORNNENVRQKM-FGZHOGPDSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50536720   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50536720 (CHEMBL4516570) Show SMILES O=C1N[C@@H]([C@H](O1)c1ccccc1)c1cccc(c1)C#Cc1ccccc1 |r| Show InChI InChI=1S/C23H17NO2/c25-23-24-21(22(26-23)19-11-5-2-6-12-19)20-13-7-10-18(16-20)15-14-17-8-3-1-4-9-17/h1-13,16,21-22H,(H,24,25)/t21-,22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research & Development Curated by ChEMBL					Assay Description Displacement of [3H]-MPEP from human mGluR5A transfected in HEK293 cells after 60 mins by microbeta liquid scintillation counting analysis				Bioorg Med Chem Lett 26: 4165-9 (2016) Article DOI: 10.1016/j.bmcl.2016.07.065 BindingDB Entry DOI: 10.7270/Q2HX1H5D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50536720 (CHEMBL4516570) Show SMILES O=C1N[C@@H]([C@H](O1)c1ccccc1)c1cccc(c1)C#Cc1ccccc1 |r| Show InChI InChI=1S/C23H17NO2/c25-23-24-21(22(26-23)19-11-5-2-6-12-19)20-13-7-10-18(16-20)15-14-17-8-3-1-4-9-17/h1-13,16,21-22H,(H,24,25)/t21-,22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research & Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated...				Bioorg Med Chem Lett 26: 4165-9 (2016) Article DOI: 10.1016/j.bmcl.2016.07.065 BindingDB Entry DOI: 10.7270/Q2HX1H5D
					More data for this Ligand-Target Pair