BDBM50538625 CHEMBL4636734

SMILES: CN(C)c1ccc(cc1)C1(CCCC1)C(=O)Nc1ccc(cc1)C(=O)NO

InChI Key: InChIKey=ZLZBJQSJXZRREI-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50538625   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50538625 (CHEMBL4636734) Show SMILES CN(C)c1ccc(cc1)C1(CCCC1)C(=O)Nc1ccc(cc1)C(=O)NO Show InChI InChI=1S/C21H25N3O3/c1-24(2)18-11-7-16(8-12-18)21(13-3-4-14-21)20(26)22-17-9-5-15(6-10-17)19(25)23-27/h5-12,27H,3-4,13-14H2,1-2H3,(H,22,26)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...				J Med Chem 63: 5956-5971 (2020)
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 2 (Homo sapiens (Human))	BDBM50538625 (CHEMBL4636734) Show SMILES CN(C)c1ccc(cc1)C1(CCCC1)C(=O)Nc1ccc(cc1)C(=O)NO Show InChI InChI=1S/C21H25N3O3/c1-24(2)18-11-7-16(8-12-18)21(13-3-4-14-21)20(26)22-17-9-5-15(6-10-17)19(25)23-27/h5-12,27H,3-4,13-14H2,1-2H3,(H,22,26)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC2 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...				J Med Chem 63: 5956-5971 (2020)
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Homo sapiens (Human))	BDBM50538625 (CHEMBL4636734) Show SMILES CN(C)c1ccc(cc1)C1(CCCC1)C(=O)Nc1ccc(cc1)C(=O)NO Show InChI InChI=1S/C21H25N3O3/c1-24(2)18-11-7-16(8-12-18)21(13-3-4-14-21)20(26)22-17-9-5-15(6-10-17)19(25)23-27/h5-12,27H,3-4,13-14H2,1-2H3,(H,22,26)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC7 pre-incubated for 15 mins before Ac-Leu-Gly-Lys(trifluroAc)-AMC substrate addition and measured after 60 mins b...				J Med Chem 63: 5956-5971 (2020)
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50538625 (CHEMBL4636734) Show SMILES CN(C)c1ccc(cc1)C1(CCCC1)C(=O)Nc1ccc(cc1)C(=O)NO Show InChI InChI=1S/C21H25N3O3/c1-24(2)18-11-7-16(8-12-18)21(13-3-4-14-21)20(26)22-17-9-5-15(6-10-17)19(25)23-27/h5-12,27H,3-4,13-14H2,1-2H3,(H,22,26)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC8 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...				J Med Chem 63: 5956-5971 (2020)
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50538625 (CHEMBL4636734) Show SMILES CN(C)c1ccc(cc1)C1(CCCC1)C(=O)Nc1ccc(cc1)C(=O)NO Show InChI InChI=1S/C21H25N3O3/c1-24(2)18-11-7-16(8-12-18)21(13-3-4-14-21)20(26)22-17-9-5-15(6-10-17)19(25)23-27/h5-12,27H,3-4,13-14H2,1-2H3,(H,22,26)(H,23,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC3 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...				J Med Chem 63: 5956-5971 (2020)
					More data for this Ligand-Target Pair