BDBM50538647 CHEMBL4648856

SMILES: ONC(=O)c1ccc(NC(=O)C2(CCCC2)c2ccc(cc2)-c2ccc3[nH]ccc3c2)cc1

InChI Key: InChIKey=FPCWVCJWBGYLMA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50538647   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50538647 (CHEMBL4648856) Show SMILES ONC(=O)c1ccc(NC(=O)C2(CCCC2)c2ccc(cc2)-c2ccc3[nH]ccc3c2)cc1 Show InChI InChI=1S/C27H25N3O3/c31-25(30-33)19-5-10-23(11-6-19)29-26(32)27(14-1-2-15-27)22-8-3-18(4-9-22)20-7-12-24-21(17-20)13-16-28-24/h3-13,16-17,28,33H,1-2,14-15H2,(H,29,32)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...				J Med Chem 63: 5956-5971 (2020)
					More data for this Ligand-Target Pair