BDBM50539934 CHEMBL4634025

SMILES: CN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3C)N3CCC(O)CC3)nc12

InChI Key: InChIKey=JJSWXDOYYGJHPA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50539934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50539934 (CHEMBL4634025) Show SMILES CN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3C)N3CCC(O)CC3)nc12 Show InChI InChI=1S/C25H28N6O2/c1-16-14-17(31-12-10-18(32)11-13-31)8-9-20(16)27-25-26-15-22-23(28-25)29(2)21-7-5-4-6-19(21)24(33)30(22)3/h4-9,14-15,18,32H,10-13H2,1-3H3,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...				J Med Chem 63: 7817-7826 (2020)
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase DCLK1 (Homo sapiens (Human))	BDBM50539934 (CHEMBL4634025) Show SMILES CN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3C)N3CCC(O)CC3)nc12 Show InChI InChI=1S/C25H28N6O2/c1-16-14-17(31-12-10-18(32)11-13-31)8-9-20(16)27-25-26-15-22-23(28-25)29(2)21-7-5-4-6-19(21)24(33)30(22)3/h4-9,14-15,18,32H,10-13H2,1-3H3,(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...				J Med Chem 63: 7817-7826 (2020)
					More data for this Ligand-Target Pair