BDBM50540314 CHEMBL4639592
SMILES: CCO[C@H]1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O
InChI Key: InChIKey=JSQMNTWGQUIWQT-OFVILXPXSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Complement factor B (Homo sapiens (Human)) | BDBM50540314 (CHEMBL4639592) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human serine protease factor B by TR-FRET based competition binding assay | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Mus musculus) | BDBM50540314 (CHEMBL4639592) | MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ... | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Homo sapiens (Human)) | BDBM50540314 (CHEMBL4639592) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati... | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair |