BDBM50540861 EFT-226::EFT226::Eft226::ZOTATIFIN::Zotatifin
SMILES: COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N
InChI Key: InChIKey=QYCXWOACFWMQFO-WZWZCULESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of human ERG by patch-clamp assay | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human HAP1 cells assessed as reduction in cell proliferation incubated for 72 hrs by CellTiter-Glo reagent based assay | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | 218 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | 2.43E+3 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50540861 (EFT-226 | EFT226 | Eft226 | ZOTATIFIN | Zotatifin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair |