BDBM50541677 CHEMBL4647629

SMILES: COCc1cccc(c1)-c1c(F)cc(cc1F)-n1nnc2c1C(=O)c1ccccc1C2=O

InChI Key: InChIKey=SGJRXNSOOQZERI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50541677   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (Homo sapiens (Human))	BDBM50541677 (CHEMBL4647629) Show SMILES COCc1cccc(c1)-c1c(F)cc(cc1F)-n1nnc2c1C(=O)c1ccccc1C2=O Show InChI InChI=1S/C24H15F2N3O3/c1-32-12-13-5-4-6-14(9-13)20-18(25)10-15(11-19(20)26)29-22-21(27-28-29)23(30)16-7-2-3-8-17(16)24(22)31/h2-11H,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...				J Med Chem 63: 7633-7652 (2020)
					More data for this Ligand-Target Pair