BDBM50541944 CHEMBL4648162
SMILES: Nc1nc(n[nH]1)N1CCC(CC1)N1Cc2ccncc2OC[C@@H]1Cc1ccc(Cl)cc1
InChI Key: InChIKey=OCSUHJZRJCUEHY-IBGZPJMESA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human)) | BDBM50541944 (CHEMBL4648162) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
OncoArendi Therapeutics S.A. Curated by ChEMBL | Assay Description Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitin... | ACS Med Chem Lett 11: 1228-1235 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50541944 (CHEMBL4648162) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
OncoArendi Therapeutics S.A. Curated by ChEMBL | Assay Description Displacement of Tracer Red from human ERG by fluorescence polarization assay | ACS Med Chem Lett 11: 1228-1235 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Chitinase 1 (Homo sapiens (Human)) | BDBM50541944 (CHEMBL4648162) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
OncoArendi Therapeutics S.A. Curated by ChEMBL | Assay Description Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using ... | ACS Med Chem Lett 11: 1228-1235 (2020) | |||||||||||
More data for this Ligand-Target Pair |