| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acidic mammalian chitinase |
|---|
| Ligand | BDBM50541944 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1985608 (CHEMBL4619014) |
|---|
| IC50 | 55±n/a nM |
|---|
| Citation |  Andryianau, G; Kowalski, M; Piotrowicz, MC; Rajkiewicz, AA; Dymek, B; Sklepkiewicz, PL; Pluta, E; Stefaniak, F; Czestkowski, W; Olejniczak, S; Mazur, M; Niedziejko, P; Koralewski, R; Matyszewski, K; Gruza, M; Zagozdzon, A; Salamon, M; Rymaszewska, A; Welzer, M; Dzwonek, K; Golab, J; Olczak, J; Bartoszewicz, A; Golebiowski, A Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett11:1228-1235 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acidic mammalian chitinase |
|---|
| Name: | Acidic mammalian chitinase |
|---|
| Synonyms: | AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 52266.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BZP6 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
|
|
|
|---|
| BDBM50541944 |
|---|
| n/a |
|---|
| Name | BDBM50541944 |
|---|
| Synonyms: | CHEMBL4648162 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H26ClN7O |
|---|
| Mol. Mass. | 439.941 |
|---|
| SMILES | Nc1nc(n[nH]1)N1CCC(CC1)N1Cc2ccncc2OC[C@@H]1Cc1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
