BDBM50543963 CHEMBL4636680

SMILES: Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc1ccc2c(c1)oc(cc2=O)-c1ccccc1

InChI Key: InChIKey=YYTRBOXSWSKPID-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50543963   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Topoisomerase I/II (Homo sapiens (Human))	BDBM50543963 (CHEMBL4636680) Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc1ccc2c(c1)oc(cc2=O)-c1ccccc1 Show InChI InChI=1S/C24H21NO4S/c1-15-11-16(2)24(17(3)12-15)30(27,28)25-19-9-10-20-21(26)14-22(29-23(20)13-19)18-7-5-4-6-8-18/h4-14,25H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
Prof John Barnabas Post Graduate School of Biological Studies Curated by ChEMBL					Assay Description Inhibition of human DNA topoisomerase 2 catalytic activity using supercoiled pRYG DNA as substrate measured after 45 mins in presence of ATP by agaro...				Bioorg Med Chem Lett 30: (2020)
					More data for this Ligand-Target Pair