BindingDB PrimarySearch_ki

Search and Browse
- Target
- Compound
- Special tools
- Citation
- Special Data Sets
- Other Databases
  - PDB 85% 100% Seq ID
  - UniProtKB/Swiss-Prot
  - UniProtKB/TrEMBL
  - PubMed
Download
- All Compounds & Data
- Target Names &
  - Ki IC50 Kd EC50
  - ΔG° ΔH° -TΔS°
Enter Data

null

SMILES: C[C@@H](OCc1ccccc1)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccc(cc1)-c1ccccc1)C#N

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50549376
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cathepsin B (Homo sapiens (Human))	BDBM50549376 (CHEMBL4762161) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin B using Z-Phe-Arg-AMC fluorogenic peptide as substrate preincubated for 2 mins followed by substrate addition and measu...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115827 BindingDB Entry DOI: 10.7270/Q2CR5XZ7
TBA					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50549376 (CHEMBL4762161) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin S				Citation and Details Article DOI: 10.1016/j.bmc.2020.115827 BindingDB Entry DOI: 10.7270/Q2CR5XZ7
TBA					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM50549376 (CHEMBL4762161) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human cathepsin K using Z-Leu-Arg-AMC as substrate measured after 20 mins				Citation and Details Article DOI: 10.1016/j.bmc.2020.115827 BindingDB Entry DOI: 10.7270/Q2CR5XZ7
TBA					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50549376 (CHEMBL4762161) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin L				Citation and Details Article DOI: 10.1016/j.bmc.2020.115827 BindingDB Entry DOI: 10.7270/Q2CR5XZ7
TBA					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50549376 (CHEMBL4762161) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin B at pH 4.5 using Z-Phe-Arg-AMC fluorogenic peptide as substrate preincubated for 2 mins followed by substrate addition...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115827 BindingDB Entry DOI: 10.7270/Q2CR5XZ7
TBA					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50549376 (CHEMBL4762161) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin B at pH 6 using Z-Phe-Arg-AMC fluorogenic peptide as substrate preincubated for 2 mins followed by substrate addition a...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115827 BindingDB Entry DOI: 10.7270/Q2CR5XZ7
TBA					More data for this Ligand-Target Pair