null
SMILES: Nc1nc2sc(CCCc3cc(cs3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human)) | BDBM50557570 (CHEMBL4761741) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 8.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116093 BindingDB Entry DOI: 10.7270/Q2RF5ZQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folate receptor alpha (Homo sapiens (Human)) | BDBM50557570 (CHEMBL4761741) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116093 BindingDB Entry DOI: 10.7270/Q2RF5ZQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proton-coupled folate transporter (Homo sapiens (Human)) | BDBM50557570 (CHEMBL4761741) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116093 BindingDB Entry DOI: 10.7270/Q2RF5ZQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reduced folate transporter (Homo sapiens (Human)) | BDBM50557570 (CHEMBL4761741) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116093 BindingDB Entry DOI: 10.7270/Q2RF5ZQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folate receptor beta (Homo sapiens (Human)) | BDBM50557570 (CHEMBL4761741) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter... | Citation and Details Article DOI: 10.1016/j.bmc.2021.116093 BindingDB Entry DOI: 10.7270/Q2RF5ZQT | |||||||||||
More data for this Ligand-Target Pair |