null
SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3CCC[C@@H]3NC(=O)C=C)nc2n(C)c1=O
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM50561591 (CHEMBL4793510) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 247 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human tagged FGFR2 using Y10-Sox as substrate in presence of 250 uM ATP by Omnia kinase method | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00601 BindingDB Entry DOI: 10.7270/Q2CN77NN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM50561591 (CHEMBL4793510) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 359 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of FGFR2 (unknown origin) expressed in KATO -III cells assessed as autophosphorylation after 1 hr incubation measured by Mesoscale discove... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00601 BindingDB Entry DOI: 10.7270/Q2CN77NN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 4 (Homo sapiens (Human)) | BDBM50561591 (CHEMBL4793510) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of FGFR4 (unknown origin) expressed in human Huh7 cells assessed as autophosphorylation after 1 hr incubation measured by Mesoscale discov... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00601 BindingDB Entry DOI: 10.7270/Q2CN77NN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 4 (Homo sapiens (Human)) | BDBM50561591 (CHEMBL4793510) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human wild type N-His tagged FGFR4 (460-802) using Y10-Sox as substrate in presence of 250 uM ATP by Omnia kinase method | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00601 BindingDB Entry DOI: 10.7270/Q2CN77NN | |||||||||||
More data for this Ligand-Target Pair |