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Target
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IC50
Kd
EC50
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ΔG°
ΔH°
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null
SMILES:
CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)ccc12)C(F)(F)F
InChI Key:
Find this compound or compounds like it in BindingDB or PDB:
Substructure
Similarity at least:
must be >=0.5
Exact match
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found
3
hits for monomerid = 50566150
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human))
BDBM50566150
(CHEMBL4781687)
Show SMILES
CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)ccc12)C(F)(F)F
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
0.720
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Displacement of [3H]RTX from human TRPV1 expressed in CHO cells
Citation and Details
Article DOI:
10.1021/acs.jmedchem.0c00982
BindingDB Entry DOI:
10.7270/Q2X06BSQ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human))
BDBM50566150
(CHEMBL4781687)
Show SMILES
CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)ccc12)C(F)(F)F
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
3.90
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of 30 nM capsaicin-induced calcium uptake
Citation and Details
Article DOI:
10.1021/acs.jmedchem.0c00982
BindingDB Entry DOI:
10.7270/Q2X06BSQ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human))
BDBM50566150
(CHEMBL4781687)
Show SMILES
CC1CCN(CC1)c1nc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)ccc12)C(F)(F)F
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
0.270
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human TRPV1 expressed in HEK cells assessed as inhibition of 10 nM capsaicin-induced calcium uptake by FLIPR assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.0c00982
BindingDB Entry DOI:
10.7270/Q2X06BSQ
More data for this
Ligand-Target Pair
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