BindingDB PrimarySearch

null

SMILES: CCOC(=O)C1=C(NN2CCN(CC(F)(F)F)CC2)O\C(=C/c2c[nH]c3ncccc23)C1=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50574282
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP without preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP with preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	212	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CLK1 (unknown origin) in presence of 1 mM ATP without preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	206	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CLK1 (unknown origin) in presence of 1 mM ATP with preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Cell division cycle 7-related protein kinase (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDC7 in human SW-620 cells assessed as reduction in phosphorylation of MCM2 at Ser40 residue incubated for 48 hrs by Western blot analy...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CLK2 (unknown origin) in presence of 1 mM ATP with preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	189	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GSK3alpha (unknown origin) in presence of 1 mM ATP without preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GSK3alpha (unknown origin) in presence of 1 mM ATP with preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Cell division cycle 7-related protein kinase (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDC7 in human SW-620 cells assessed as reduction in phosphorylation of MCM2 at Ser53 residue incubated for 48 hrs by Western blot analy...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50574282 (CHEMBL4868568) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CLK2 (unknown origin) in presence of 1 mM ATP without preincubation				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01319 BindingDB Entry DOI: 10.7270/Q2CJ8J97
TBA					More data for this Ligand-Target Pair