null

SMILES: C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCc1cn(CCOc2ccc(cc2)N(Cc2cccc(O)c2Cl)CC2(CCCC2)c2ccccc2F)nn1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50574416   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM50574416 (CHEMBL4877124) Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCc1cn(CCOc2ccc(cc2)N(Cc2cccc(O)c2Cl)CC2(CCCC2)c2ccccc2F)nn1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00127 BindingDB Entry DOI: 10.7270/Q26T0RG4
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50574416 (CHEMBL4877124) Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCc1cn(CCOc2ccc(cc2)N(Cc2cccc(O)c2Cl)CC2(CCCC2)c2ccccc2F)nn1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to ERalpha D538G mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00127 BindingDB Entry DOI: 10.7270/Q26T0RG4
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50574416 (CHEMBL4877124) Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCc1cn(CCOc2ccc(cc2)N(Cc2cccc(O)c2Cl)CC2(CCCC2)c2ccccc2F)nn1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to ERalpha S463P mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00127 BindingDB Entry DOI: 10.7270/Q26T0RG4
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50574416 (CHEMBL4877124) Show SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCc1cn(CCOc2ccc(cc2)N(Cc2cccc(O)c2Cl)CC2(CCCC2)c2ccccc2F)nn1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	332	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00127 BindingDB Entry DOI: 10.7270/Q26T0RG4
					More data for this Ligand-Target Pair