null
SMILES: CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM50580337 (CHEMBL5081090) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant thrombin (unknown origin) using D-Phe-Pip-Arg-pNA as substrate preincubated for 30 mins followed by substrate addition by c... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01671 BindingDB Entry DOI: 10.7270/Q2BZ69XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor activator (Homo sapiens (Human)) | BDBM50580337 (CHEMBL5081090) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human HGFA serine protease domain using Boc-QLR-AMC as substrate preincubated for 30 mins followed by substrate addition by... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01671 BindingDB Entry DOI: 10.7270/Q2BZ69XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50580337 (CHEMBL5081090) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01671 BindingDB Entry DOI: 10.7270/Q2BZ69XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease hepsin (Homo sapiens (Human)) | BDBM50580337 (CHEMBL5081090) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01671 BindingDB Entry DOI: 10.7270/Q2BZ69XG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50580337 (CHEMBL5081090) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01671 BindingDB Entry DOI: 10.7270/Q2BZ69XG | |||||||||||
More data for this Ligand-Target Pair |