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SMILES: [H][C@]12C[C@@]1([H])C(=O)N(C2)c1ncc(Cn2cc(NC(=O)c3nc(cnc3C)-c3c(F)c(Cl)ccc3C(F)F)cn2)cc1C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50582287   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM50582287 (CHEMBL5079850 | US20230286958, Example 41) Show SMILES [H][C@]12C[C@@]1([H])C(=O)N(C2)c1ncc(Cn2cc(NC(=O)c3nc(cnc3C)-c3c(F)c(Cl)ccc3C(F)F)cn2)cc1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human plasma kallikrein using fluorogenic substrate measured by microplate reader analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00085 BindingDB Entry DOI: 10.7270/Q2QJ7N5D
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM50582287 (CHEMBL5079850 | US20230286958, Example 41) Show SMILES [H][C@]12C[C@@]1([H])C(=O)N(C2)c1ncc(Cn2cc(NC(=O)c3nc(cnc3C)-c3c(F)c(Cl)ccc3C(F)F)cn2)cc1C |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2DB8609
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50582287 (CHEMBL5079850 | US20230286958, Example 41) Show SMILES [H][C@]12C[C@@]1([H])C(=O)N(C2)c1ncc(Cn2cc(NC(=O)c3nc(cnc3C)-c3c(F)c(Cl)ccc3C(F)F)cn2)cc1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2DB8609
					More data for this Ligand-Target Pair