null
SMILES: CC(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CC3)nc2C=C1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50582443 (CHEMBL5077087) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of CYP2D6 (unknown origin) | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 6 (Homo sapiens (Human)) | BDBM50582443 (CHEMBL5077087) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH | |||||||||||
More data for this Ligand-Target Pair |