BindingDB PrimarySearch

null

SMILES: COc1ccccc1-c1cc(ccc1Cl)C1CCNC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50582610
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintil...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintil...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT1DR (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT2BR (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	96	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT1AR (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT2AR (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT6R (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT1BR (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	590	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT3R (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT1ER (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 5A (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	970	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT5AR (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens)	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to 5-HT2CR (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	76	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	92	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50582610 (CHEMBL5077293) Show SMILES COc1ccccc1-c1cc(ccc1Cl)C1CCNC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair