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null

SMILES: CC1(C)CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2c(c(ccc12)C#N)P(C)(C)=O)C(F)(F)F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50583929
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM50583929 (SY-5609 \| SY5609 \| Sy 5609 \| Sy-5609) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Medicinal Molecular Design, Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2/cyclin E1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay				J Med Chem 47: 4818-28 (2004) Article DOI: 10.1021/acs.jmedchem.1c01171 BindingDB Entry DOI: 10.7270/Q2736VSR
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 12 (Homo sapiens)	BDBM50583929 (SY-5609 \| SY5609 \| Sy 5609 \| Sy-5609) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Medicinal Molecular Design, Inc. Curated by ChEMBL					Assay Description Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay				J Med Chem 47: 4818-28 (2004) Article DOI: 10.1021/acs.jmedchem.1c01171 BindingDB Entry DOI: 10.7270/Q2736VSR
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50583929 (SY-5609 \| SY5609 \| Sy 5609 \| Sy-5609) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Medicinal Molecular Design, Inc. Curated by ChEMBL					Assay Description Inhibition of CDK9/cyclin T1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay				J Med Chem 47: 4818-28 (2004) Article DOI: 10.1021/acs.jmedchem.1c01171 BindingDB Entry DOI: 10.7270/Q2736VSR
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50583929 (SY-5609 \| SY5609 \| Sy 5609 \| Sy-5609) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a
Institute of Medicinal Molecular Design, Inc. Curated by ChEMBL					Assay Description Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...				J Med Chem 47: 4818-28 (2004) Article DOI: 10.1021/acs.jmedchem.1c01171 BindingDB Entry DOI: 10.7270/Q2736VSR
					More data for this Ligand-Target Pair