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Enter Data

null

SMILES: Clc1ccc(NC(=O)NCCc2cccc(Br)c2)cc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50584053
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50584053 (CHEMBL5086597) Show SMILES Clc1ccc(NC(=O)NCCc2cccc(Br)c2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	724	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at N-terminal tagged human CB1 receptor transfected with HEK293 cells assessed as forskolin-stimulated cAMP level in presence of ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01432 BindingDB Entry DOI: 10.7270/Q2XP78TM
TBA					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50584053 (CHEMBL5086597) Show SMILES Clc1ccc(NC(=O)NCCc2cccc(Br)c2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric antagonist activity against human CB1 receptor expressed in HEK293 cells membrane measured after 60 mins by [35S]GTPgammaS binding assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01432 BindingDB Entry DOI: 10.7270/Q2XP78TM
TBA					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50584053 (CHEMBL5086597) Show SMILES Clc1ccc(NC(=O)NCCc2cccc(Br)c2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells overexpressing Galpha16 assessed as inhibition of CP55940-stimul...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01432 BindingDB Entry DOI: 10.7270/Q2XP78TM
TBA					More data for this Ligand-Target Pair