BindingDB PrimarySearch

null

SMILES: Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50584720
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to TrkB (unknown origin) assessed as inhibition constant by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to TrkA (unknown origin) assessed as inhibition constant by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to TrkC (unknown origin) assessed as inhibition constant by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to TrkA G595R mutant (unknown origin) assessed as inhibition constant by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to TrkA G667C mutant (unknown origin) assessed as inhibition constant by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TrkA G595R mutant (unknown origin) by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TrkA G667C mutant (unknown origin) by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human DDR1 in presence of ATP by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
Ephrin type-A receptor 8 (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human EphA8 in presence of ATP by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fes/Fps (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human FES in presence of ATP by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Mer in presence of ATP by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase FRK (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PTK5 in presence of ATP by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human RSE in presence of ATP by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 2 (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human TAK1 in presence of ATP by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TrkC (unknown origin) by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TrkB (unknown origin) by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TrkA (unknown origin) by radiometric assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of wild type TrkA (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of wild type TrkB (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50584720 (CHEMBL5088153) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of wild type TrkC (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01597 BindingDB Entry DOI: 10.7270/Q2377DMN
TBA					More data for this Ligand-Target Pair