Search and Browse
Download
Enter Data
null
SMILES: NS(=O)(=O)c1ccc(CNc2ccnc(Nc3cccc(NC(=O)N4CCCC4)c3)n2)cc1
InChI Key:
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 305 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human FMS (538 to end residues) using KKKSPGEYVNIEFG as substrate measured after 40 mins in presence of [gamma33P]ATP by ra... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase 17A (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of tracer K9 from NLuc fused DRAK1 (unknown origin) expressed in HEK293 cells by NanoBRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| MAP/microtubule affinity-regulating kinase 3 (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of tracer K9 from NLuc fused MARK3 (unknown origin) expressed in HEK293 cells by NanoBRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of NanoLuc-fused TYK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of tracer K5 from NLuc fused TBK1 (unknown origin) expressed in HEK293 cells by NanoBRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TYK2 (875 to end residues) using GGMEDIYFEFMGGKKK as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of NanoLuc-fused CSF1R (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| MAP/microtubule affinity-regulating kinase 4 (Homo sapiens (Human)) | BDBM50585194 (CHEMBL5087006) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of tracer K5 from NLuc fused MARK4 (unknown origin) expressed in HEK293 cells by NanoBRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00440 BindingDB Entry DOI: 10.7270/Q27S7SND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
