null
SMILES: Fc1cc2ncc3ncn(-c4ccc(CC#N)cc4)c3c2cc1-c1ccc2[nH]ccc2c1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human)) | BDBM50585938 (CHEMBL5087942) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of full-length human MEK1 by TR-FRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02192 BindingDB Entry DOI: 10.7270/Q26Q225J | |||||||||||
More data for this Ligand-Target Pair |