null

SMILES: Fc1cc2ncc3ncn(-c4ccc(CC#N)cc4)c3c2cc1-c1ccc(Oc2ccccn2)cc1Cl

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50585939   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50585939 (CHEMBL5094993) Show SMILES Fc1cc2ncc3ncn(-c4ccc(CC#N)cc4)c3c2cc1-c1ccc(Oc2ccccn2)cc1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CYP3A4 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02192 BindingDB Entry DOI: 10.7270/Q26Q225J
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50585939 (CHEMBL5094993) Show SMILES Fc1cc2ncc3ncn(-c4ccc(CC#N)cc4)c3c2cc1-c1ccc(Oc2ccccn2)cc1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full-length human MEK1 by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02192 BindingDB Entry DOI: 10.7270/Q26Q225J
					More data for this Ligand-Target Pair