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SMILES: Fc1cc2ncc3ncn(C4CCN(CC#N)CC4)c3c2cc1-c1ccc(Oc2ccccn2)cc1Cl

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50585940   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))		BDBM50585940
PNG
(CHEMBL5090765)
Show SMILES Fc1cc2ncc3ncn(C4CCN(CC#N)CC4)c3c2cc1-c1ccc(Oc2ccccn2)cc1Cl
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MMDB

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n/an/a 70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of full-length human MEK1 by TR-FRET assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c02192
BindingDB Entry DOI: 10.7270/Q26Q225J
More data for this
Ligand-Target Pair