BDBM5077 1,2,4-Oxadiazole Analogue 7::4-[(2S)-2-acetamido-2-{[(3-{[4-(trifluoromethyl)phenyl]methyl}-1,2,4-oxadiazol-5-yl)methyl]carbamoyl}ethyl]phenoxyphosphonic acid

SMILES: CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NCc1nc(Cc2ccc(cc2)C(F)(F)F)no1

InChI Key: InChIKey=IBEJTPIBRTVDAR-SFHVURJKSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5077   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5077 (1,2,4-Oxadiazole Analogue 7 | 4-[(2S)-2-acetamido-...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NCc1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C22H22F3N4O7P/c1-13(30)27-18(10-14-4-8-17(9-5-14)36-37(32,33)34)21(31)26-12-20-28-19(29-35-20)11-15-2-6-16(7-3-15)22(23,24)25/h2-9,18H,10-12H2,1H3,(H,26,31)(H,27,30)(H2,32,33,34)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.28E+5	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM5077 (1,2,4-Oxadiazole Analogue 7 | 4-[(2S)-2-acetamido-...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NCc1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C22H22F3N4O7P/c1-13(30)27-18(10-14-4-8-17(9-5-14)36-37(32,33)34)21(31)26-12-20-28-19(29-35-20)11-15-2-6-16(7-3-15)22(23,24)25/h2-9,18H,10-12H2,1H3,(H,26,31)(H,27,30)(H2,32,33,34)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM5077 (1,2,4-Oxadiazole Analogue 7 | 4-[(2S)-2-acetamido-...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NCc1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C22H22F3N4O7P/c1-13(30)27-18(10-14-4-8-17(9-5-14)36-37(32,33)34)21(31)26-12-20-28-19(29-35-20)11-15-2-6-16(7-3-15)22(23,24)25/h2-9,18H,10-12H2,1H3,(H,26,31)(H,27,30)(H2,32,33,34)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair