null

SMILES: CCc1sc2c(NC(=O)C3(O)CC3)c(OC)nn2c1-c1c(OC)cc(COC)cc1OC

InChI Key: InChIKey=NKFLEHUEOAHIFI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5108   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM5108 (US8530504, 76) Show SMILES CCc1sc2c(NC(=O)C3(O)CC3)c(OC)nn2c1-c1c(OC)cc(COC)cc1OC |(4.71,2.99,;3.94,1.65,;2.4,1.65,;1.49,2.9,;.03,2.42,;-1.44,2.9,;-1.91,4.36,;-.88,5.51,;-1.36,6.97,;.62,5.19,;.23,3.7,;1.96,5.96,;1.71,4.1,;-2.34,1.65,;-3.88,1.65,;-4.65,.32,;-1.44,.41,;.03,.88,;1.49,.41,;1.89,-1.08,;.8,-2.17,;-.69,-1.77,;-1.77,-2.86,;1.2,-3.66,;2.69,-4.05,;3.09,-5.54,;2,-6.63,;2.4,-8.12,;3.78,-2.97,;3.38,-1.48,;4.47,-.39,;5.96,-.79,)| Show InChI InChI=1S/C22H27N3O6S/c1-6-15-18(16-13(29-3)9-12(11-28-2)10-14(16)30-4)25-20(32-15)17(19(24-25)31-5)23-21(26)22(27)7-8-22/h9-10,27H,6-8,11H2,1-5H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Eisai R&D Management Co., Ltd. US Patent					Assay Description A binding competition experiment with CRF was conducted by the SPA (GE Healthcare) method using a 96-well plate.				US Patent US8530504 (2013) BindingDB Entry DOI: 10.7270/Q29885NS
					More data for this Ligand-Target Pair